YOR Health: Premium Quality Health Products


	Science

Kevin S. Hughes, MD
Member of
YOR Scientific Advisory Board

BIO - Kevin S. Hughes, MD
Dr. Hughes is a member of the Department of Surgical Oncology at the Massachusetts General Hospital where he is the Co-Director of the Avon Comprehensive Breast Evaluation Center and Surgical Director of the Breast and Ovarian Cancer Genetics and Risk Assessment Program. He serves as the Medical Director of the Bermuda Cancer Genetics and Risk Assessment Clinic, providing access to genetic testing for Bermudians. He is a graduate of Dartmouth College and Dartmouth Medical School. He trained at the Mercy Hospital of Pittsburgh for general surgery, followed by a fellowship in surgical oncology at the National Cancer Institute.

Dr. Hughes is an Associate Professor of Surgery at Harvard Medical School and was formerly on the faculty of Tufts University, the University of California, Davis and Brown University. Dr. Hughes is actively involved in research regarding the genetics, screening, diagnosis and treatment of breast cancer and is actively involved in the development of Electronic Health Records that decrease clinician workload, having co-authored the HL7 standard for transmitting family history information, which has been approved as the ANSI standard.

Dr. Hughes CURRICULUM VITAE:
HMS CURRICULUM VITAE
DATE PREPARED: April 15, 2008

PART I: General Information

Name:

Kevin S. Hughes M.D., FACS
Surgical Director, Breast Screening Co-Director,
Avon Comprehensive Breast Evaluation Center

Education:

	1976	B.A., Dartmouth College
	1979	M.D., Dartmouth Medical School

Postdoctoral Training:

	1979-1984	Resident, General Surgery, Mercy Hospital, Pittsburgh, PA
	1984-1986	Fellow, Surgical Oncology, National Cancer Institute, Bethesda, MD

Licensure and Certification:

	1985	American Board of Surgery Certification
	1988	Massachusetts Medical License
	1995	Re-certification, American Board of Surgery
	2006	CITI Refresher course in the Protection of Human Research Subjects
	2006	Re-certification, American Board of Surgery

Academic Appointments:

	1986-1987	Assistant Professor of Surgery, Brown University
	1987-1988	Assistant Professor of Surgery, University of California, Davis, CA
	1989-1993	Clinical Instructor in Surgery, Harvard, Medical School, Boston, MA
	1996-2000	Assistant Professor of Surgery, Tufts University, Boston, MA
	2000-	Assistant Professor of Surgery, Harvard Medical School (HMS), Boston, MA
	2008-	Associate Professor of Surgery, Harvard Medical School (HMS), Boston, MA

Hospital or Affiliated Institution Appointments:

	1987-1988	Surgeon, Sacramento Medical Center, Sacramento, CA
	1991-2000	Senior Staff, Lahey Clinic, Burlington, MA
	1995-2000	Cancer Liaison Physician, American College of Surgeons, Lahey Clinic, Burlington, MA
	1997-2000	Associate Staff, Department of Surgery, Symmes Hospital and Medical Center, Arlington, MA
	2002-	Surgeon, Newton-Wellesley Hospital (NWH), Wellesley, MA
	2005-	Associate Visiting Surgeon, Massachusetts General Hospital (MGH), Boston, MA

Major Administrative Responsibilities:

	1986-1987	Director, Division of Surgical Oncology, Roger Williams General Hospital, Providence, RI
	1991-2000	Co-Director: Breast Cancer Treatment Center, Lahey Clinic, Burlington, MA
	1992-1993	Acting Chairman: Lahey Clinic Department of Research
	1993-1995	Chairman: Quality Breast Care Team, Lahey Clinic, Burlington, MA
	1994-2000	Director, The Breast Center, Lahey Clinic, Burlington, MA
	1994-2000	Co-Director, Women’s Health Center, Clinic North Shore, Peabody, MA
	1994-2000	Medical Director, The Breast Cancer Risk Assessment Clinic, Lahey Clinic North Shore, Peabody, MA
	2000-	Co-Director, Breast and Ovarian Cancer Genetics and Risk Assessment Program, MGH, Boston, MA
	2001-	Co-Director, Avon Comprehensive Breast Evaluation Center, MGH, Boston, MA
	2006	Medical Director, Bermuda Cancer Genetics and Risk Assessment Clinic

Major Committee Assignments:

Hospital

1989-2000

Cancer committee, Lahey Clinic Medical Center

1992-1993

Cancer Center Task Force, Lahey Clinic

1992-1993

Chairman, Research Policy Committee, Lahey Clinic

1992-1993

Education Executive Committee, Lahey Clinic

1992-1993

Research Fellow Review Committee, Lahey Clinic

1992-1993

Dana Fellow Review Committee, Lahey Clinic

1992-1993

Acting Chairman, Institutional review Board, Lahey Clinic

1992-1994

Chairman, Breast Subcommittee of the Clinical Effectiveness Committee, Lahey Clinic

1994-2000

Operating Room Committee, Lahey Clinic North Shore

1996-1998

Co-Champion, Accelerating Clinical Improvement Team for Breast Cancer Care, Lahey Clinic

1998-1999

Cancer Center Planning Committee, Lahey Clinic

1998-1999

Women’s Health Task Force, Member, Lahey Clinic

1998-2000

Chairman, Genetics Advisory Board, Lahey Clinic

2001-2005

Longitudinal Medical Record Steering Committee, MGH

2002-2005

Specialty Specific OR Team-Surgical Oncology

2002-2005

Breast Center Committee, Newton Wellesley Hospital

2002-

Longitudinal Medical Record Clinician Working Group

2007-

Privacy and Confidentiality Committee, MGH

2007-

Partners Healthcare Personalized Medicine Clinical Decision Support Roadmap

	Regional
	1993-1994	Massachusetts Department of Public Health
		Breast Cancer Quality Assurance Task Force


National:
1988-1989		Professional Education Committee, American Cancer Society, Sacramento CA
	1988	Special Review Committee, Diagnostic Imaging Trial, National Cancer Institute.
	1988	Special Review Committee of RFA National Collaborative Diagnostic Imaging Trial, National Cancer Institute
1994-		National Consortium of Breast Centers, Inc.
		1994-1998 Chairperson, Breast Center Registry Committee
		1995- Trustee-at-Large
		1996-2002 Vice President
		2005-2007 President Elect
		2005-2007 Chairman Program Committee
		2007- President
2004-		HL7 Clinical Genomics Special Interest Group
		2007- Co-Chair
2007-		American Society of Breast Surgeons Database Committee
2007-		Information Technology and Outcomes Committee, National Accreditation Program for Breast Centers
2008-		Information Technology and Outcomes Committee, National Accreditation Program for Breast Centers
2008-		American Society of Breast Surgeons, Informatics Ad Hoc Committee

Professional Societies:

	1981-	American Medical Association, Member
	1982-	American College of Surgeons, Associate Fellow
		1989 Fellow
		1989-1994 Cancer Committee, Massachusetts Chapter
	1987-	American Society of Clinical Oncology, Member
	1988-1991	American Society of Colon and Rectal Surgeons, Member
	1990-	New England Cancer Society, Member
	1991-	Society of Surgical Oncology, Member
	1993-1995	Association of Community Cancer Centers, Member
	1993-	Boston Surgical Society. Member
	1995-	National Institutes of Health Alumni Association, Member
	1996-	New England Surgical Society, Member
	2001-	American Society of Breast Disease, Member
	2001-	MGH Surgical Society, Member
	2007-	American Society of Breast Surgeons Database Committee, Member

Community Service Related to Professional Work:

	1992-2002	Scientific Advisory Board for Continuing Medical Education Valleylab, Inc., Boulder, CO
	1996-1997	Chairman, Breast Cancer Medical Advisory Board, OncorMed, Inc., Gaithersburg, MD
	1999-2001	Medical Advisory Board, Assurance Medical, Hopkinton, MA
	1999-2002	Scientific Advisory Board, Imagyn, Inc., Irvine, CA

Editorial Boards

	2006	Surgery, ad hoc reviewer
	2006	Menopause Journal, ad hoc reviewer
	2007	Cancer, ad hoc reviewer
	2007	Drugs and Aging, ad hoc reviewer
	2008	Breast Cancer Research and Treatment, ad hoc reviewer
	2008	New England Journal of Medicine, ad hoc reviewer
	2008	BMC Women’s Health, ad hoc reviewer

Awards and Honors:

	1973	National Merit Scholar
	1982	Laboratory Research Award, Southwestern Pennsylvania Chapter, American College of Surgeons
	1983	Laboratory Research Award, Southwestern Pennsylvania Chapter, American College of Surgeons
	1995	Proffered Paper Award, Annual Meeting, The American Society of Breast Disease
	2001	Sixth Annual Partners in Excellence Award, Avon Breast Cancer Project

PART II: Research, Teaching, and Clinical Contributions

A. Narrative Report of Research, Teaching, and Clinical Contributions

At the MGH Department of Surgical Oncology, my practice involves the screening, diagnosis, and management of breast cancer and hereditary susceptibility to breast and ovarian cancer. I work closely with multiple specialties in my role as Co-Director of the Avon Comprehensive Breast Evaluation Center and the Surgical Director of the Breast and Ovarian Cancer Genetics and Risk Assessment Program. Additionally, I serve as the Medical Director of the Bermuda Cancer Genetics Risk Assessment Program.

My first major research effort was to work collaboratively with 24 institutions world wide to establish a single centralized database of liver resections for metastatic colorectal cancer information. Our findings set the standard indications for liver resection.

In the late 1980s, my focus shifted to the multidisciplinary care of breast disease, working for the widespread implementation of this approach through my writings and lectures, and serving as the 2006 and 2007 Program Chair for the National Consortium of Breast Centers, and now as its President.

My research focus is now the identification and management of women at high risk for breast and ovarian cancer. I established the Lahey Clinic Risk Assessment Center in 1995 (Recognized by the Oncology Round Table as a model risk clinic), and instituted genetic testing at that institution.

We have shown that the current methods of identification are grossly inefficient, and that most patients are not identified until after they develop cancer. We have also shown that current approaches to management lack the ability to be successful at a large scale.

To solve these problems, I have organized the development of an open-source Tablet PC-based system that efficiently collects risk information, and shares data betweendepartments, thus greatly decreasing the time and resources needed to manage individuals. This system is in use at multiple centers throughout the country.

On a national level, I served as the principal investigator of a Breast Cancer Cooperative Group trial that changed medical practice by showing that radiation is not always necessary for the woman over age 70.

I Co-Chair the Clinical Genomics Special Interest Group of HL7. We developed the national standard (ANSI) for the transmission of family history information between electronic medical records.

At an international level, we are using this system to identify every person who carries a BRCA1 or BRCA2 mutation on Bermuda. I plan to develop a better understanding of this gene at the population level while simultaneously improving the management of these individuals.

I am actively involved in the training of surgical residents and breast surgery fellows. I have co-authored at least one paper with each Fellow, providing guidance and mentorship. I have instructed internal medicine and obstetrics-gynecology residents in the office practice of breast disease. I spend a significant amount of time speaking about breast disease to medical students, physicians, nurses, and the lay public at Continuing Medical Education (CME) courses and invited presentations. I have served as course director for multiple CME offerings as described in my CV.

In summary, we will set the standard for the identification and management of individuals at high risk for all hereditary diseases, and the transmission of that information between systems, departments, and institutions.

B. Funding Information

Past Research Funding:

	1987-2000	National Surgical Adjuvant Project for Breast and Bowel Cancer 1989-2000, Principal Investigator, Lahey Clinic
	1994-1996	Susan G. Komen Breast Cancer Foundation Boston Race for the Cure™ “Tumor marker analysis of ductal carcinoma in situ.”
	1996-1999	Susan G. Komen Breast Cancer foundation Boston Race for the Cure™ “Identification of women at high risk of developing breast cancer.”
	2000-2002	P.I. Ross Perot Foundation (PI) A study of hereditary breast and ovarian cancer in Bermuda
	2001-2002	P.I. Susan G. Komen Breast Cancer Foundation “Assessing Your Risk for Hereditary Breast and Ovarian Cancer” (Website)
	2001-2002	Salary support from the Breast Cancer SPORE for a database programmer for one year to create a uniform data collection system for the high-risk clinics at MGH, Dana Farber Cancer Institute, and Beth Israel Hospital.

Current Research Funding:

	1993-2019	National Cancer Institute, Study Chairman, Cancer and Leukemia Group B. Protocol CALGB 9343. “Economic evaluation of lumpectomy, Tamoxifen, and irradiation of the breast compared with lumpectomy plus Tamoxifen in women 70 years of age or older who have carcinoma of the breast that is less than or equal to 4 cm. and clinically negative nodes: A Phase III study” (Dates open ended.)
	2007-	Friends of the MGH Cancer Center Tablet Computer translation project. Write and implement an upgrade to our Tablet PC software that allows translation of the questions into Spanish, and develops a template for future translation projects. (Dates open ended.)

Pending Research Funding:

	2008-2013	R01 (Ozanne) NIH/NCI Translating advances in breast cancer prevention to clinical care Goals: The goal of the proposed research is to translate advances in breast cancer prevention to clinical care. This study will implement and evaluate a clinical decision aid designed to inform and guide breast cancer prevention decision-making. Role: Co-Investigator
	2008-2011	Kaiser Project Director’s Fund (Selby) Kaiser Permanente and Robert Wood Johnson Foundation TITLE: Optimizing Prevention Of Vascular Disease In A Large Population GOAL: To produce an Open Source Solution that will allow the collection of data regarding family history and other cardiovascular risk factors from patients, clinicians, and other data sources and create an algorithm to predict risk. ROLE: Subcontract P.I. (20%)
	2008-2011	CDC U18 (Haddow)
		CDC
		TITLE: Routine Family History/BRCA Testing to Avoid Cancer: Clinical Validity/Utility GOAL: To test the validity of various guidelines and algorithms in the identification of women with BRCA1 and BRCA2 mutations ROLE: Subcontract PI (30%)
	2008-2013	CDMRP 2008 Breast Cancer Research Program (Esserman)
		DOD
		TITLE: Democratizing Information to Transform Care and Drive Innovation in Breast Care Management
		GOAL: To create a breast cancer care model (eCareNet) that relies on the secure sharing, or “democratization,” of input of and access to information, in order to appreciably empower and improve the patient experience and dramatically accelerate the pace of learning and innovation.
		ROLE: Consultant (5% time)
	2008-2011	RO1 (Taghian)
		NIH
		TITLE: Early Identification & Treatment of Lymphedema in Women with Breast Cancer: Evaluation of Early Use Compression & Its Impact on Quality of Life & Function.
		GOAL: Evaluate the early of use of early intervention as well as the impact on function and quality of life due to mild and moderate volume lymphedema in women with breast cancer.
		ROLE: Consultant (5%)
	2008-2011	CDC FOA (Lopresti)
		CDC
		TITLE: Primary Screening for BRCA 1&2 Using Electronic Health Records in Community Practices
		GOAL: To develop and implement an EHR based system to identify and manage women at high risk of BRCA1/2 mutations in a large population.
		ROLE: Subcontract (15%)

C. Report of Current Research Activities

Prospective Clinical Trials

	1989-1991	Intraoperative radio-Immunodetection of colorectal metastases using an intraoperative gamma detection probe, Lahey Clinic, P.I.
	1990-	A comparison of lumpectomy plus Tamoxifen with and without radiotherapy in women 70 years of age or older who have clinical stage I, ER+ breast carcinoma, Study Chairman for National Study
	1993-1995	CEA scan for the detection of axillary metastases from breast cancer, Lahey Clinic, P.I.
	1995-1997	Biofield electrophysiology study of breast lesions, Lahey Clinic P.I.
	1996-1998	Assurance Medical pressure sensing study of breast lesions, Lahey Clinic, P.I.
	1996-1998	Study of BRCA1 and BRCA2 Mutations in the Ashkenazi Population, Lahey Clinic, P.I.
	1997-2000	Computerized thermographic imaging of breast, lesions, Lahey Clinic, P.I.
	1998-2002	The GRACE Protocol, Lahey Clinic, P.I.
	2002-2004	Computerized thermographic imaging of breast. P.I.
	2003-2006	Measuring the Quality of Decisions in Breast Cancer, American Cancer Society.
	2005-2006	A study of the firmness and elasticity of breast masses, Medical Tactile Incorporated
	2006	Identification of women at high risk for hereditary breast/ovarian cancer syndrome using high through-put history collection: rationale and implementation.

D. Report of Teaching

1. Local contributions

a. Harvard Medical School - Medical School Students

2001

Introduction to Clinical Medicine, HMS

Preceptor

1 student each week

contact time:
2 hours/week
for 6 weeks

b. Graduate Medical School Courses

2001-2006

Resident Breast Clinic, MGH

Preceptor

2 to 5 surgical residents each week

contact time:
12 hours/month

2000-

Internal Medicine Residency Breast Clinic, MGH

Preceptor

1 resident each week

contact time:
12 hours/month

	c. Local Invited Presentations

	Grand Rounds
	2001	Surgery, “Hereditary breast/ovarian cancer syndrome: Clinical aspects,” MGH, Boston, MA
	2001	Gynecology, “Hereditary breast/ovarian cancer syndrome: What the gynecologist needs to know,” MGH, Boston, MA
	2002	Surgery, “Hereditary Breast/Ovarian Cancer Syndrome,” Newton Wellesley Hospital, Newton, MA
	2002	Gynecology, “Management of breast lumps and abnormal mammograms,” MGH, Boston, MA
	2002	Surgical Grand Rounds, “Hereditary Breast/Ovarian Cancer Syndrome,” Newton Wellesley Hospital, Newton, MA
	2005	Breast Cancers in the Elderly, MGH Grand Rounds, Boston, MA
	2007	“Genetic Testing for Inherited Cancers”. Cambridge, MA

	Chief Rounds
	2005	Management of Benign Breast Problems, MGH, Boston, MA

	Local Invited Presentations
	2001	Quarterly Seminar “Management of the high risk patient,” Mount Auburn Hospital, Cambridge, MA
	2001	Quarterly Seminar “Surgical management of breast cancer,” Mount Auburn Hospital, Cambridge, MA
	2001	Dana Farber Partners Breast Conference “Breast cancer in the elderly,” Boston, MA
	2001	MGH Breast Conference “Breast cancer in the elderly,” Boston, MA
	2002	Chelsea Health Center Medical Group Meeting, Management of Common Breast Problems, Chelsea, MA
	2002	3rd Annual “Partners Physicians Day,” “Breast Cancer: Issues and Controversies,” Boston, MA
	2003	Genetic Testing for Breast Cancer, Vincent Symposium, Boston, MA Given to members of the Vincent Society, donors to the obstetrics program at MGH, and the lay public.
	2004	Large Scale Identification of Women at High Risk of Hereditary Breast and Ovarian Cancer, Partners Informatics Research Seminar, Wellesley, MA
	2004	Breast Cancer in the Elderly, Boston Surgical Society, Boston, MA
	2005	Radiation Therapy is Not Always Needed After Breast Conservation Debate, 11th Annual Perspectives in Breast Cancer, Boston, MA
	2005	Harvard Breast Conference Debate: Radiation Therapy is Not Always Needed After Breast Conservation, Boston, MA
	2005	Transplantation in Turkey, MGH/Johns Hopkins Surgery Conference, Boston, MA
	2006	Management of Patients with Positive Sentinel Nodes, 12 th Annual Perspectives in Breast Cancer, Boston, MA
	2006	Options for Breast Cancer Care in the Elderly, Advances in Cancer Management for the Surgeon, Boston, MA
	2006	Determining If Your Patient is Truly at High Risk for Developing Breast Cancer, Advances in Cancer Management for the Surgeon, Boston, MA
	2007	Advances in Cancer Management “Prevention and Risk Stratification”. Boston, MA (A CME course offered by Surgical Oncology at MGH, to attending physicians.)
	2008	Nuts and Bolts of Genetics and Genetic Research for Research Nurses and Study Coordinators. “Open Source Software Package.” Boston, MA (An MGH seminar for researchers in Genetics)

	d. Continuing Medical Education
	2002	Harvard Course: ‘Two Ends of the Breast Cancer Spectrum: The DCIS Epidemic and Advanced Disease Treatment Challenges,” “Local Therapy for DCIS: Surgery and Radiation Issues,” Boston, MA
	2003	“Breast Cancer Care in the Elderly,” Harvard Medical School Continuing Education Course, Cambridge, MA
	2004	“Breast Cancer – High Risk Patients,” Partners Update in General Internal Medicine for Subspecialists (A CME Course), Boston, MA

	e. Advisory and Supervisory Responsibilities in Clinical or Laboratory Setting

	2003-2005	Supervising resident clinic, MGH, Boston, MA, Four Residents for 60 hrs/year
	2003-	Attending for gynecology inpatient resident service, MGH, Boston, MA. Eight Residents for 336 hrs/year
	2003-	Attending for Gynecologic Oncology Fellows, MGH three Fellows for 500 hrs/year

g. Advisees and Trainees

Training Duration	Name	Current Position
2005-2006	Master’s Thesis Advisor for Adrienne O’Connell	Boston University School of Health Administration
2006-	Mentor for Brian Drohan	Ph.D candidate, UMass, Lowell, MA
2006-	Mentor for John Sharko	Ph.D candidate UMass, Lowell, MA.

2. Regional, national, and international contributions

	National Grand Rounds
	2001	Hackensack University Medical Center Grand Rounds, “Management of Recurrent Breast Cancer,” Hackensack, NJ
	2002	Riverside Hospital Grand Rounds, “Approaches to the Diagnosis of Breast Cancer using Various Biopsy Techniques,” Valhalla, NY
	2004	Breast Cancer in the Elderly, Yale Cancer Center Grand Rounds, New Haven, CT

	International Grand Rounds
	2001	King Edward VII Hospital Grand Rounds “Hereditary Breast/Ovarian Cancer in Bermuda,” Bermuda

	Regional Invited Presentations
	2001	Preceptor, University of Massachusetts, Boston, MA, Graduate Program in Computer Science
	2001	Southern Maine Medical Center Grand Rounds, Sentinel Node Biopsy for Breast Cancer,” Kennebunkport, ME
	2001	Nurse Practitioner Association for Continuing Education “Screening, diagnosis and management of breast cancer,” Newport, RI
	2002	Sturdy Memorial Hospital, “Hereditary Breast/Ovarian Cancer Syndrome,” Attleboro, MA
	2003- 2005	Preceptor, University of Massachusetts, Boston, MA, Graduate Program in Computer Science
	2003	Challenges in Breast Cancer Management, Mammography Seminar and Panel, Burlington, MA
	2004	Breast Cancer in Older Women, NPACE, Hyannis, MA
	2004	Management of Breast Problems of the Primary Care Physician, Geiger Gibson Health Center, Dorchester, MA
	2004	Breast Cancer in Older Women, St. Anne’s Hospital, Fall River, MA
	2004	Surgical Advances in Breast Cancer Management, St. Elizabeth’s Hospital Cancer Course, Boston, MA
	2005	Treatment of Breast Cancer in the Elderly, New Direction in Breast Cancer Care Symposium, Elliott Hospital, Bedford, MA
	2005	Breast Conservation and Tamoxifen vs. Radiation, Update in Breast Cancer, Manchester, NH
	2005	Proposal for a Newton Wellesley Hospital Project: Large Scale Identification of Women at High Risk of Hereditary Breast and Ovarian Cancer, NWH President’s Council, Newton, MA
	2005	Genetic Testing for BRCA1 and BRCA2, St. Luke’s Hospital Grand Rounds, New Bedford, MA
	2005	Proposal for a Newton Wellesley Hospital Project: Large Scale Identification of Women at High Risk of Hereditary Breast and Ovarian Cancer, NWH President’s Council, Newton, MA
	2005	Hereditary Breast and Ovarian Cancer: Identification of Women at Risk, Charlton Memorial Hospital, Fall River, MA
	2006	Gave opinion on article: “New Gene Tied to Added Breast Cancer,” ABC News Now’s “Healthy Life,” Needham, MA
	2006	Hereditary Breast and Ovarian Cancer: Identification of Women at Risk, Charlton Memorial Hospital, MA
	2006	Large Scale Identification of High Risk Women, NWH Leadership Project, Newton, MA
	2007	Review of the San Antonio Breast Cancer Symposium “Breast Cancer in the Elderly,” Providence, RI
	2007	Rhode Island Surgical Society Rhode Island Hereditary in Cancer Management “Genetics (Genomics) in Surgical Management of Breast Cancer,” Providence, RI
	2007	Omnia Education Innovations in Gynecology “Breast and Ovarian Cancer Screening,” Cambridge, MA
	2008	Commentary on the Use of Radiation After Breast Conservation, Cambridge Hospital Tumor Board, Cambridge, MA
	2008	Omnia Education-Women’s Health Annual Visit. “Breast and Ovarian Cancer,” Cambridge, MA.
	2008	Myriad Genetic Laboratories. “Industrial Level Identification of Women at High Risk of Breast Cancer: Reducing the Incidence, Morbidity and Mortality of Breast and Ovarian Cancer,” Sudbury, CT
	2008	Stamford Hospital. “Industrial Level Identification of Women at High Risk of Breast Cancer: Reducing the Incidence, Morbidity and Mortality of Breast and Ovarian Cancer,” Stamford, CT
	2008	Jordan Hospital. “Industrial Level Identification of Women at High Risk of Breast Cancer: Reducing the Incidence, Morbidity and Mortality of Breast and Ovarian Cancer,” Plymouth, MA
	2008	TEC Summer Science Institute. “Breast Cancer,” Dedham, MA
	National Invited Presentations
	2001	National Consortium of Breast Centers Annual Meeting “Managing the patient with an abnormal mammogram,” Las Vegas, NV
	2001	Multidisciplinary Breast Conference “Biopsy options for the patient with an abnormal mammogram,” Magee Women’s Hospital, Pittsburgh, PA
	2002	American Society of Breast Surgeons Third Annual Meeting, “Breast Cancer: Prevention and Risk Assessment,” Boston, MA
	2002	Society for Women’s Imaging, “Thermal Imaging in the Diagnosis of Breast Cancer,” Boston, MA
	2002	Riverside Hospital Grand Rounds, “Approaches to the Diagnosis of Breast Cancer using Various Biopsy Techniques,” Valhalla, NY
	2003	Understanding Hereditary Risks for Familial Breast Cancer, Dallas American Board of Surgery, Dallas, TX
	2004	Breast Cancer in the Elderly, New York Metropolitan Cancer Group, Inc Annual Breast Cancer Symposium, New York, NY
	2004	Large Scale Identification of Women at High Risk of Hereditary Breast and Ovarian Cancer, Myriad Genetics: Genetic Counselor Course, Salt Lake City, UT
	2005	The Use of the HL7 Standard to Promote Interoperability in Family History Software, CDC Conference on Genomics and Public Health, Atlanta, GA
	2005	Commentary on the Use of Radiation After Breast Conservation, ASTRO Annual Meeting, Denver, CO
	2005	Large Scale Identification of Women at High Risk of Breast/Ovarian Cancer, Texas Oncology Retreat and Strategic Planning Meeting, Dallas, TX
	2005	HL7 Working Group Meeting, Scottsdale, AZ
	2005	Large Scale Identification of Women at High Risk of Hereditary Breast and Ovarian Cancer, National Consortium of Breast Centers, Las Vegas, NV
	2005	Organization of a High Risk Clinic, American Society of Breast Surgeons, Los Angeles, CA
	2005	Breast Cancer in the Elderly, American Society of Breast Diseases, Las Vegas, NV
	2006	Management of Hereditary Breast Cancer: How Many Women Are At Risk for Hereditary Breast Cancer? NCBC, Las Vegas, NV
	2006	Radiation in the Elderly, NCBC, Las Vegas, NV
	2006	Lumpectomy Plus Tamoxifen with or without Irradiation in Women 70 Years of Age or Older with Early Breast Cancer: A Report of Further Follow-Up, San Antonio, TX
	2007	17 th Annual Interdisciplinary Breast Center Conference “Large scale Identification of women at high risk of Breast Cancer,” Las Vegas, NV
	2007	Hackensack University Medical Center Grand Rounds “Large scale Identification of women at high risk of Breast Cancer”. Hackensack, NJ
	2007	American Society of Clinical Oncology “Management of the Frail Elderly with Breast Cancer-Alternatives in Surgery, Systematic Therapy and Radiation Therapy,” Chicago, IL
	2007	National Comprehensive Cancer Network Breast Cancer in the Older Woman Task Force “Management of the Axilla in the Elderly Breast Cancer Patient,” Philadelphia, PA
	2007	Myraid “Large Scale Identification of Women at High Risk,” Bridgeport, CT
	2007	Genetics Conference “The Use of Family History in Identifying High Risk Patients,” Salt Lake City, UT
	2007	Genetics Conference “Patient Entered Family History in the High Risk Cancer Setting,” Salt Lake City, UT
	2007	Women’s Health Annual Visit Full-Day Symposium “Breast and Ovarian Cancer Screening,” Dearborn, MI
	2007	San Antonio Cancer Symposium “Identifying High-Risk Postmenopausal Women as Candidates for Raloxifene Therapy in a Surgical Practice,” San Antonio, TX
	2007	Geriatric Oncology Consortium’s Fifth Annual Meeting “Advancing Cancer Care in Elderly: Clinical Options in Breast and Prostate Cancer,” Washington DC
	2008	Oncology Hematology Care “Breast Cancer,” Cincinnati, OH
	2008	The 13 th Annual Multidisciplinary Symposium on Breast Disease. “What Everyone Should Know About Breast Health,” Amelia Island, FL
	2008	The 35 th Annual Symposium For the Breast Cancer Specialist. “Breast Cancer in the Elderly: A Selected Approach for a Unique Population,” New York, NY
	2008	18 th Annual National Interdisciplinary Breast Center Conference. “Identification and Management of the Woman at High Risk for Hereditary Breast and Ovarian Cancer,” Las Vegas, NV
	2008	18 th Annual National Interdisciplinary Breast Center Conference. “Intro/Opening General Membership Meeting.” Las Vegas, NV
	2008	Myriad Genetic Laboratories. “Hereditary Cancer Syndromes, Patient Identification and Treatment Options,” Orlando, FL
	2008	Omnia Education. “Breast and Ovarian Cancer: Screening and Prevention,” Chicago, IL
	2008	9 th Annual Meeting of American Society of Breast Surgeons. “ Saving Time and Work: Patient Data Entry.” New York City, NY
	2008	Omnia’s Education Innovations in Gynecology CME Symposium. “ Breast and Ovarian Cancer Screening,” Chicago, IL
	2008	VA Genomic Medicine Advisory Committee Meeting. “Large Scale Identification of Women at High Risk of Hereditary Breast Ovarian Cancer: Clinical Decision Support, Interoperability, and the Potential of the Electronic Health Record,” Washington DC
	2008	St. Vincent’s Medical Center. “Genetic Testing for Hereditary Breast and Ovarian Cancer.” South Bend, IN
	International Invited Presentations
	2001	4th UAE Cancer Conference “Molecular basis of breast cancer,” Abu Dhabi, United Arab Emirates (UAE)
	2001	4th UAE Cancer Conference “Surgical management of breast cancer,” Abu Dhabi, UAE
	2001	4th UAE Cancer Conference “Screening and diagnosis of breast cancer,” Abu Dhabi, UAE
	2004	Hereditary Breast Cancer. Identification of High Risk Women, Varese Update on Breast Cancer, Varese, Italy
	2004	Organization of a Breast Center, Varese Update on Breast Cancer, Varese, Italy
	2004	DCIS: Treatment Options, King Hussein Cancer Center Oncology Conference, Amman, Jordan
	2004	Sentinel Node Biopsy, King Hussein Cancer Center Oncology Conference, Amman, Jordan
	2004	“Hereditary Breast Cancer in Bermuda,” Hamilton, Bermuda, given to the lay public.
	2005	Bermuda TB and Cancer Society Public Lecture on Hereditary Cancer in Bermuda, Hamilton, Bermuda, given to the lay public
	2005	Sentinel Node Biopsy for Breast Cancer, King Hussein Cancer Center Course on Women’s Cancers, Amman, Jordan
	2006	Identification and Management of Women at High Risk of Hereditary Breast and Ovarian Cancer, IISS Course: Breast Cancer and Melanoma: Biology, Diagnosis and Therapy, Varese, Italy
	2006	Breast Cancer Treatment in the Elderly: Individualizing Treatment, IISS Course: Breast Cancer and Melanoma: Biology, Diagnosis and Therapy, Varese, Italy
	2006	Neoadjuvant Chemotherapy in Breast Cancer, King Hussein Cancer Center Course on Women’s Cancers, Amman, Jordan
	2006	Hereditary Breast and Ovarian Cancer, King Hussein Cancer Center Course on Women’s Cancers, Amman, Jordan
	2007	Arab Medical Association Against Cancer “Breast Cancer in the Elderly,” Amman, Jordan
	2007	Arab Medical Association Against Cancer “Surgical challenges in the era of neoadjuvant therapy”. Amman, Jordan

	Professional and Educational Leadership
	1987	Course Director, Ultrasonic Liver Surgery: Brown University, Providence, RI
	1988	Course Director, Ultrasonic Liver Surgery: University of California, Davis, CA
	1989	Course Director, Ultrasonic Liver Surgery:Lahey Clinic, Burlington, MA (Spring)
	1989	Course Director, Ultrasonic Liver Surgery:Lacey Clinic Medical Center, Burlington MA (Fall)
	1990	Course Director, Current Concepts in Hepatobiliary Surgery: Lahey Clinic, Burlington, MA
	1990	Course Director, Current Concepts in Surgical Oncology, San Francisco, CA
	1991	Course Director, Topics in Colon and Breast Cancer Treatment, Chicago, IL
	1996	Course Director, Hereditary Breast Cancer: An Update for Clinicians, Washington, D.C
	2004	Course Co-Director, Varese Update on Breast Cancer, University of Insubria, Varese, Italy
	2006	Program Chairman, Annual Meeting of the National Consortium of Breast Centers, Las Vegas, NV
	2007	Program Co-Chairman, Annual Meeting of the National Consortium of Breast Centers, Las Vegas, NV

E. Report of Clinical Activities

As previously described, I am a practicing physician actively involved in research and teaching.

Patient load

Each year I evaluate and manage approximately 900 new patients with breast problems, and perform close to 500 operations.

Clinical contributions

I have had a leadership role in the development of numerous breast centers (Brown University, 1987, University of California at Davis, 1988, Lahey Clinic Breast Cancer Treatment Center, 1990, Lahey Peabody Breast Center, 1995, Avon Center, MGH, 2000) and have consulted for numerous hospitals developing breast centers (Most recently, at Newton Wellesley Hospital).

I played an integral role in bringing risk assessment and genetic testing to the Lahey Clinic in 1995, founding the Lahey Breast Cancer Risk Assessment Clinic, and serving as Chairman, Lahey Clinic Genetics Advisory Board, where I lead the effort to develop the Lahey guidelines for genetic testing for breast and ovarian cancer susceptibility.